Treatments

Mesothelioma Symposium 2009 – Raja Flores, MD – Pleural Mesothelioma

More videos of symposium presentations are available at www.curemeso.org. Dr. Flores’ presentation at the International Symposium on Malignant Mesothelioma organized by the Mesothelioma Applied Research Foundation.

Mesothelioma Symptom Relief and Palliative Care for Breathlessness

Mesothelioma symptom relief is the central focus of care for the mesothelioma patient deemed incurable. Pain management will vary with each patient. The mesothelioma patient’s pre-existing conditions and exacerbating conditions are factors in determining the best mesothelioma symptom relief and palliative care plan available. However, there are similarities in mesothelioma treatment and symptomatic relief for pleural mesothelioma, pericardial mesothelioma and peritoneal mesothelioma.

Almost every cancer patient, mesothelioma cancer patients included, experiences painful difficulty breathing during the last stages of cancer. Medical studies have indicated that as many as 70% of terminal cancer patients experience painful difficulty breathing. With diseases such as pleural mesothelioma, pericardial mesothelioma and lung cancer, painful breathing and shortness of breath occurs during all of the cancer stages, not just the terminal stages.

Difficulty breathing is frightening for the mesothelioma patient, the caregiver and family members. The fear of imminent death and helplessness suddenly becomes unexpectedly more real. Mesothelioma symptom relief for breathing difficulties should include emotional care as well as physical symptom relief. Relaxation techniques should be taught, and it should be stressed that there needs to be adaptations to daily activities to reduce breathing difficulty. Lifestyle changes will be in order to control mesothelioma breathing difficulties, and the most stubborn mesothelioma patients need to be convinced that this is the best mesothelioma treatment for them. Defining a new lifestyle as a “well deserved vacation” can help instigate a transition.

Mesothelioma symptom relief for physical pain from breathing difficulties can be provided by learning, advising and providing for the patient the best position of their body for proper air flow. A fresh stream of air from a window or a fan can provide mesothelioma symptom relief during breathing difficulty. Teaching the patient hyperventilation techniques can be very useful for the patient’s self-monitoring of their mesothelioma treatment. A mesothelioma patient with trouble breathing needs to learn how to purse their lips at the first sign of breathing trouble, stay calm, relax their shoulders, back, neck and arms, then “flop” themselves into relaxation. Until this technique is mastered, learning how to breathe out slowly is an important step in breathing management.

Mesothelioma patients must realize that anxiety breeds anxiety. If a patient is afraid that they are going to die at the moment they are experiencing breathing difficulty, their body will respond by producing more anxiety, and more breathlessness. This is an emotional and physical response, not merely emotional.

Oxygen is sometimes prescribed for mesothelioma symptom relief; however physicians report that some patients become unnecessarily dependent on oxygen. For other patients, oxygen is their lifeline of mesothelioma treatment. Oxygen therapy also requires a review of whether intermittent or continuous therapy provides the best relief for their mesothelioma symptoms. Mesothelioma treatment with oxygen therapy will also consider whether to use oxygen tanks or an oxygen concentrator.

There are also medications for mesothelioma symptom relief of breathlessness. Anxiolytic drugs Lorazepam, Diazepam, Midazolam, and Methotrimeprazine can be prescribed for mesothelioma treatment of breathlessness. Benzodiazepines are anxiolytic drugs that have a sedative effect and use muscle relaxation as pain treatment of breathlessness.

Mesothelioma symptom relief for breathing requires educating the patient, the caregiver and the family in palliative care. Mesothelioma treatment for pain also requires monitoring and adapting mesothelioma pain treatment plans to meet the patient’s medical needs, as well as their emotional needs. Listening to the patient’s perception of pain is crucial to determining the appropriate pain management treatment for mesothelioma symptoms. The patient feels the pain. With mesothelioma symptom relief and palliative care from knowledgeable and loving caregivers, the patient can enjoy the last years of their life as pain free as medical science allows.

Mesothelioma Lawyers In High Demand

Mesothelioma is a rare, deadly cancer that strikes nearly 3,000 people in the United States every year. The average life expectancy of a person suffering from mesothelioma is a mere six months from diagnosis. Most victims are men over the age of forty who have worked with asbestos or in buildings where asbestos was present.
Because mesothelioma is caused by direct exposure to asbestos or asbestos dust, and nearly 30 million tons of asbestos was used in buildings of every description until the mid 1970′s, it has kept Mesothelioma lawyers in high demand, as they pursue Mesothelioma settlements for the victims and their families. If your home was built prior to the mid 1970′s it should be inspected for asbestos. Asbestos was used in insulation, to include boiler and pipe insulation, fireproofing spray; firebrick, gunite and many construction materials, such as roof, floor and ceiling tiles.
Mesothelioma can develop up to 50 years after direct or indirect exposure to asbestos. Early symptoms can include shortness of breath, pain in the lower back or in the sides of your chest. Unfortunately, these symptoms are common to many types of illness, and diagnosis is often delayed because of this. If you suspect that you or your loved one may have mesothelioma, it is critical that you inform your doctor of your asbestos exposure. Other less common symptoms may include unexplained weight loss, fatigue, difficulty swallowing, cough, fever and sweats.
If you or your loved one is diagnosed with mesothelioma you should contact a mesothelioma lawyer immediately to see if you have a mesothelioma case. Try to write down any source of possible exposure regardless of time passed and try to locate the responsible parties. Your mesothelioma lawyer will advise you on the statute of limitations. If you have a family member who has died from mesothelioma you may still be eligible to file a claim. If you were never directly exposed to asbestos but contracted mesothelioma from indirect exposure, such as asbestos dust brought home on a family members clothing, you may also be eligible to file a mesothelioma case.
While a settlement can not erase the fact that you or your loved one have contracted mesothelioma, it can bring comfort, security and stability to a family in crisis.
In order to cope with a diagnosis of Mesothelioma, it is crucial to know three important facts about this disease. First, one needs to know what Mesothelioma is. Second, it is imperative to know what causes this deadly cancer. Lastly, one must know as much as possible about the three forms of Mesothelioma. They are Pleural Mesothelioma, Peritoneal Mesothelioma and Pericardial Mesothelioma.
Mesothelioma is a rare cancer that is attributed to repeated exposure to asbestos. Individuals most susceptible for developing Mesothelioma are those who work in shipyards, asbestos mines, manufacture asbestos products, and those employed in the heating and construction trades. Mesothelioma does not usually become evident until 20 to 60 years after exposure to asbestos.
Mesothelioma gets its name from the word mesothelium. The mesothelium is the protective lining that covers and helps to protect most of the body’s internal organs. This form of cancer invades the mesothelium. Pleural Mesothelioma, Peritoneal Mesothelioma and Pericardial Mesothelioma are aggressive forms of cancer that attack the protective lining of the lungs, abdomen and heart, respectively.
Pleural Mesothelioma is the most prevalent form of Mesothelioma. It presents itself in the Pleura, or lining of the inside of the chest that house the lungs. When asbestos is mined, manufactured or disturbed, asbestos particles escape into the air. These particles are easily inhaled or swallowed. Over an extended period of time, these inhaled and ingested asbestos particles may eventually cause normal cells in the Pleura to become abnormal, causing Pleural Mesothelioma.
Peritoneal Mesothelioma is a more rare form of Mesothelioma. This type of cancer originates in the Peritoneum or the membranous lining of the abdomen that encloses the stomach, intestines, liver, spleen, and pancreas. Peritoneal Mesothelioma accounts for less than a quarter of all Mesothelioma cases.
Pericardial Mesothelioma is a cancer invades the Pericardium, or the membrane that surrounds the heart. This condition causes severe heart problems, and most people who contract this asbestos-related cancer eventually die from heart failure.
The Pleura is thought to be most susceptible to Mesothelioma. Due to this membrane surrounding the lungs it is in direct contact with asbestos fibers when inhaled. This would explain why Pleural Mesothelioma is the most common form of this deadly cancer.
It has been suggested that when asbestos-containing fibers are ingested or inhaled they can be picked up by the lymph nodes and spread to other parts of the body. This may account for cases of Peritoneal Mesothelioma and Pericardial Mesothelioma.
Chronic exposure to asbestos, after a latency period of approximately 20 to 60 years, can cause Mesothelioma. If you have been diagnosed with Mesothelioma it is imperative to know what it is, what causes it and its three major forms; Pleural Mesothelioma, Peritoneal Mesothelioma and Pericardial Mesothelioma. Once you know what form of this asbestos related cancer you are up against it will aid you in seeking appropriate treatment options.
In addition to seeking aggressive medical treatment, you need to find out the cause of your asbestos-related cancer. Since all three forms are caused by contact with asbestos, think back on all the jobs you’ve had, and where you were exposed to asbestos. Next, seek the advice of an attorney who is familiar with litigating Mesothelioma lawsuits. Your attorney will help you in documenting your exposure to asbestos even if it occurred many years ago, and also documenting the physical and emotional damage that your diagnosis of Pleural Mesothelioma, Peritoneal Mesothelioma or Pericardial Mesothelioma has caused for you.

Mesothelioma Symptoms and Tests for Mesothelioma

Mesothelioma symptoms are progressively slow and take years to surface. Early medical testing to confirm the etymology of mesothelioma symptoms can add years on to your life, and can even offer you salvation from a normally fatal disease. If you’ve been exposed to asbestos and are experiencing mesothelioma symptoms, notify your doctor of any asbestos exposure and monitor your symptoms from their onset. Even short term asbestos exposure can result in non-fatal pleural diseases. Keeping a journal of your mesothelioma symptoms can assist you and your physician in medical diagnosis, and it may contribute to an asbestos claim.

The symptoms of mesothelioma will differ based on their origin. Pleural mesothelioma starts in the lung area, peritoneal mesothelioma starts in the abdomen area, and pericardial mesothelioma starts dangerously close to the heart. Benign and malignant mesothelioma have similar symptoms, and similar tests. Weight loss is a well-documented symptom in the majority of mesothelioma cases. Abdominal pain is a primary symptom of peritoneal mesothelioma. Both pleural mesothelioma symptoms and peritoneal mesothelioma symptoms include chest pain and shortness of breath.

Pleural mesothelioma medical tests look at the pleural lining, lung fluid, inflammatory conditions, tissue, blood counts and cells to help determine what type of pleural activity is going on inside your lungs. The tests will help diagnose whether your mesothelioma symptoms might be due to pleural effusion, diffuse pleural thickening, asbestosis or other asbestos caused diseases that aren’t necessarily as dangerous as pleural mesothelioma, but can be due to their respiratory nature.

A CT scan will identify pleural thickening better than a chest X-ray. MRI and PET scans can then determine whether the pleural disease is diffuse pleural thickening or if it is malignant pleural mesothelioma. Blood tests can also give an indication of the possibility of cancer. Once cancer is the suspected cause of your mesothelioma symptoms, a biopsy will take place. Thoracentesis removes pleural fluid for diagnosis. Thoracoscopy uses a “camera” (endoscope) inserted into the chest for diagnose and a sample of tissue is taken at that time. Pleural mesothelioma starts in the pleural region, but it will progress to attach other major body organs, such as the heart or abdominal area.

Abdominal pain and bowel restrictions are common peritoneal mesothelioma symptoms. If peritoneal mesothelioma is suspected after the traditional CT, MRI and PET scans, a peritoneoscopy or paracentesis is likely. Peritoneoscopy is done in the hospital with a camera-like instrument called a peritoneoscope. Peritoneal mesothelioma has also been incidentally discovered while performing similar procedures involving infertility examinations on women. A fluid sample is obtained in a process called paracentesis. This involves a needle going into your abdomen to get a sample of the fluid.

Pericardial mesothelioma symptoms always involve severe chest pain. This is a cancer invading the sac over the heart. The pericardial mesothelioma patient may even experience heart failure. Blood tests, CT scans, MRIs and PETs are just the beginning of pericardial mesothelioma medical tests. There will be pulmonary tests and potentially dangerous biopsies. Pericardial mesothelioma symptoms are frequently misdiagnosed. The cancer is very rare, and many well-known diseases display the same symptoms as pericardial mesothelioma. It is often during surgery that pericardial mesothelioma is discovered, and then it is usually too late.

Mesothelioma symptoms can be suggestive of many cancers or diseases. Medical testing for mesothelioma symptoms requires a long battery of tests to discover symptom origins. Medical tests for mesothelioma symptoms can expedite mesothelioma treatment. Symptoms take decades to surface. Start recording your mesothelioma symptoms and start your tests early. It’s better to test for mesothelioma symptoms early, before it’s too late.

Mesothelioma Mesomark Blood Test

MESOSELIOMA MESOMARK BLOOD TEST
The Food and Drug Administration (FDA) approved the MESOMARK assay to help monitor response to treatment in malignant mesothelioma patients. The MESOMARK test signifies the beginning of a new era in monitoring mesothelioma malignancies,” said Dr. W. Jeffrey Allard, vice president and chief scientific officer of Fujirebio Diagnostics. “As the first in-vitro test for patients with this aggressive disease, it will enable doctors to more accurately detect recurrence and monitor treatment of patients.”
The MESOMARK Assay test kit was developed to measure levels of a biomarker, mesothelin, in serum. Biomarkers are substances found in higher-than-normal concentrations in the blood, urine or body tissues of patients with certain types of cancers. The test may be used to monitor patients confirmed as having mesothelioma, for recurrence in patients following surgery, or for measuring response to therapies.
“Current diagnostic tests are less than ideal for quantification of changes in tumor volume, which is key to managing the disease,” continued Allard. “As the MESOMARK results correlate with tumor volume*, it provides a much needed tool for monitoring patient status. It is our plan to collect additional data in the future to support the use of the test to detect mesothelioma.”

MESOMARK test are now making it possible – with a simple blood test -to monitor response to treatment and to detect recurrence following treatment. This provides an important head start to patients racing against this aggressive cancer. “The Meso Foundation is the national research funding, patient support and advocacy organization dedicated to eradicating mesothelioma as a life-threatening disease.
Those wishing to take part in MESOMARK testing will be asked to provide one or more samples of blood. The blood samples will then be sent to a national reference laboratory for testing. In conjunction with other clinical and laboratory data obtained by your doctor, decisions regarding your treatment and care may be simplified. You may discontinue testing at any time.

LINKS:
Diagnisis Mesothelioma